BI 1467335

CAS No. 1478364-68-9

BI 1467335 ( PXS-4728A;PXS-4728 )

Catalog No. M12040 CAS No. 1478364-68-9

BI 1467335 (PXS-4728A,PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 56 Get Quote
5MG 87 Get Quote
10MG 147 Get Quote
25MG 312 Get Quote
50MG 500 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    BI 1467335
  • Note
    Research use only, not for human use.
  • Brief Description
    BI 1467335 (PXS-4728A,PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.
  • Description
    BI 1467335 (PXS-4728A,PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.Steatohepatitis,Phase 2 Clinical
  • Synonyms
    PXS-4728A;PXS-4728
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Steatohepatitis

Chemical Information

  • CAS Number
    1478364-68-9
  • Formula Weight
    316.80
  • Molecular Formula
    C15H21FN2O2.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(C)NC(=O)C1=CC=C(C=C1)OCC(=CF)CN.Cl
  • Chemical Name
    (E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schilter HC, et al. Respir Res. 2015 Mar 20;16:42.

2. Jarnicki AG, et al. Br J Pharmacol. 2016 Nov;173(22):3161-3175.

3. Katagiri D, et al. Respir Res. 2015 Mar 20;16:42.
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