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BI 1467335

CAS No. 1478364-68-9

BI 1467335( PXS-4728A | PXS-4728 )

Catalog No. M12040 CAS No. 1478364-68-9

BI 1467335 (PXS-4728A,?PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BI 1467335
  • Note
    Research use only, not for human use.
  • Brief Description
    BI 1467335 (PXS-4728A,?PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM.
  • Description
    BI 1467335 (PXS-4728A,?PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis.Steatohepatitis,Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PXS-4728A | PXS-4728
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Other Indications
  • Indication
    Steatohepatitis

Chemical Information

  • CAS Number
    1478364-68-9
  • Formula Weight
    316.8
  • Molecular Formula
    C15H21FN2O2.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (789.14 mM)
  • SMILES
    CC(C)(C)NC(=O)C1=CC=C(C=C1)OCC(=CF)CN.Cl
  • Chemical Name
    (E)-4-((2-(aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schilter HC, et al. Respir Res. 2015 Mar 20;16:42. 2. Jarnicki AG, et al. Br J Pharmacol. 2016 Nov;173(22):3161-3175. 3. Katagiri D, et al. Respir Res. 2015 Mar 20;16:42.
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